Leukemia Inhibitory Factor introduction Leukemia inhibitory factor, or LIF, is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate. LIF derives its name from its ability to induce the terminal differentiation of myeloid leukemic cells,thus preventing their continued growth. Other properties attributed to the cytokine…
IGFL1 introduction GFL1 is an insulin-like growth factor-1 (Insulin growth factor-like family member 1IGFL1), which belongs to the IGF-like (IGFL) family. In 2006, research by Peter Emtage et al. discovered a new family of human secreted proteins and named it the IGF-like (IGFL) family. The IGF-like (IGFL) gene encodes a protein of about 100 amino…
GFRAL Function in CACS introduction There are obese patients around everyone. According to the statistics of the World Health Organization, about 400 million people in the world are obese, and the number of diagnosed cancer patients in the world has reached 19.3 million, and this number is still growing. Every year, tens of thousands of…
New MSI-H Cancer Treatment introduction An eLife study shows that WRN (Werner syndrome helicase) holds promise for the treatment of patients with high-grade microsatellite instability (MSI) tumors. Microsatellite instability (MSI) refers to the loss of mismatch repair (MMR) gene function, resulting in the loss of erroneous insertions and deletions of DNA. Growth or truncation of MSI…
CD14 (cluster of differentiation 14), formerly known as MY23 antigen, is a surface antigen and a member of the cell surface glycoprotein family. The protein encoded by the CD14 gene is preferentially expressed in monocytes/macrophages.
Hydrogel Introduction What Is Hydrogel? Hydrogel is a crosslinked hydrophilic polymer that does not dissolve in water. They are highly absorbent yet maintain well-defined structures. These properties underpin several applications, especially in the biomedical area. Many hydrogels are synthetic, but some are derived from nature. Hydrogel is a kind of extremely hydrophilic three-dimensional network structure…
What Is Resistin Introduction Resistin, originally described as an adipocyte-specific hormone, has been suggested to be an important link between obesity, insulin resistance and diabetes. Although its expression was initially defined in adipocytes, significant levels of resistin expression in humans are mainly found in mononuclear leukocytes, macrophages, spleen and bone marrow cells. Increasing evidence indicates…
What is Ovalbumin? Introduction Ovalbumin (abbreviated OVA) is the main protein found in egg white, making up approximately 55% of the total protein. The function of ovalbumin is unclear, but it is thought to be a storage protein. Ovalbumin belongs to the serpins. However, unlike other serpins, ovalbumin is unable to inhibit serine proteases. Albert…
S100 Protein Introduction What’s S100 Protein? The S100 proteins are a family of low molecular-weight proteins found in vertebrates, characterized by two calcium-binding sites that have helix-loop-helix (“EF-hand-type”) conformation. The S100 protein family is composed of 21 members that exhibit a high degree of structural similarity, but are not functionally interchangeable. S100 family members function…
Hormones are chemical messengers that are secreted directly into the blood, which carries them to organs and tissues of the body to exert their functions. These signals tell your body what to do and when to do it. Hormones are essential for life and your health.